Sunday Jun 16, 2024

E65 Hilary

Responding to recent podcast feedback. Hilary at one time had two years off kratom, but after a step backwards returning to capsule use, is now reinvesting in her recovery by being active in the quitting community, service work, healthy eating, going to the gym, support from loved ones and pursuing goals for her future.

RESOURCE OF THE WEEK ARTICLES

Annuar, Nur Aisyah Khairul, Ummi Kalthum Azlan, Ahmed Mediani, Xiaohui Tong, Rongchun Han, Ebtesam Al-Olayan, Syarul Nataqain Baharum, et al. 2024. “An Insight Review on the Neuropharmacological Effects, Mechanisms of Action, Pharmacokinetics and Toxicity of Mitragynine.” Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 171 (February): 116134. https://doi.org/10.1016/j.biopha.2024.116134.

Huestis, Marilyn A., Martin A. Brett, John Bothmer, and Ramsey Atallah. 2024. “Human Mitragynine and 7-Hydroxymitragynine Pharmacokinetics after Single and Multiple Daily Doses of Oral Encapsulated Dried Kratom Leaf Powder.” Molecules 29 (5): 984. https://doi.org/10.3390/molecules29050984.

Mongar, Pooja, Amit Jaisi, Thammasin Inkviya, Juraithip Wungsintaweekul, and Kamonthip Wiwattanawongsa. 2024. “Effects of Itraconazole on Pharmacokinetics of Mitragynine and 7-Hydroxymitragynine in Healthy Volunteers.” ACS Pharmacology & Translational Science, February. https://doi.org/10.1021/acsptsci.3c00335.

Tanna, R.S., James T. Nguyen, Deena L. Hadi, Matthew E. Layton, John R. White, Nadja B. Cech, Nicholas H. Oberlies, Allan E. Rettie, Kenneth E. Thummel, and Mary F. Paine. 2023. “Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom.” Clinical Pharmacology and Therapeutics 113 (6): 1315–25. https://doi.org/10.1002/cpt.2891.

KRATOM IN THE HEADLINES

A Deadly Get-Together With a Plant-Based Preparation of Kratom (medscape.co.uk)

https://www.medscape.co.uk/viewarticle/deadly-get-together-plant-based-preparation-kratom-2024a10004tp

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