Kratom Abstinence
Interviewing people in recovery from kratom abuse or addiction, or experts in the field.
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Episodes
Sunday Nov 05, 2023
Sunday Nov 05, 2023
Jacob and Charlie read some listener comments and discuss the growth of the kratom industry and the podcast. Nick is almost three years clean off of kratom and shares how we need more kratom-specific recovery awareness and resources. Decima talks about kratom regulation in Mississippi.
Study Jacob referenced about explosion of kratom market: https://www.maximizemarketresearch.com/market-report/kratom-market/216883/?fbclid=IwAR2L2C_K14LIfBlgvYYfvh22K8RPacRsj1RFr7YRbvZVsaAba4DpyN00JoA
RESOURCE OF WEEK
Exercise to help with withdrawals and recovery https://www.washingtonpost.com/wellness/2023/04/26/addiction-recovery-exercise-treatment/
KRATOM IN THE HEADLINES
Kratom/CDB chain owner bustedhttps://www.msn.com/en-us/news/other/update-biloxi-councilman-indicted-on-drug-conspiracy-records-destruction-charges-after-raids/ar-AA1h72RZ
Kratom Regulation in Mississippi https://www.mpbonline.org/blogs/news/mississippi-lawmakers-hearing-evidence-to-ban-kratom-in-the-2023-legislative-session/
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CONTACT THE SHOW
Voice: 313-437-7720
Email: kratomsobriety@gmail.com
https://kratomsobriety.com
Sunday Oct 29, 2023
Sunday Oct 29, 2023
Decima & Charlie discuss getting things done without kratom. Eva shares how she quit kratom after a near-death experience and a relapse.
RESOURCE OF WEEK
Google Sheet tapering tool: https://docs.google.com/spreadsheets/d/13QpmFV45wUXWuh6YDQPvk51Da3gJMkh4X1WSLpsEwzE/edit?usp=sharing
KRATOM IN THE HEADLINES
Shot of Joy FDA Warning Letter: https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/shot-joy-llc-665936-09252023
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CONTACT THE SHOW
Voice: 313-437-7720
Email: kratomsobriety@gmail.com
https://kratomsobriety.com
Sunday Oct 22, 2023
Sunday Oct 22, 2023
Jacob and Decima discuss MAT opiate blockers versus replacement therapy. Chad talks about getting up to 12 kava/kratom drinks a day, and the horrible cracked and bloody hands, and significant weight loss that off accompanies it. Lots of references to libido and negative impacts with use of subs and kratom!
Charlie's "Kicking K" Spotify Playlist featuring Social Distortion's Ball & Chain:
https://open.spotify.com/playlist/03TW7IiY8S5TvHeqMynCV4?si=63c0ec9815f34bcd
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CONTACT THE SHOW
Voice: 313-437-7720
Email: kratomsobriety@gmail.com
https://kratomsobriety.com
Wednesday Oct 18, 2023
Wednesday Oct 18, 2023
Mr. Ericson's reporting on the kratom industry for Court House News:
https://www.courthousenews.com/can-kratom-kill/
https://www.courthousenews.com/addiction-and-the-kratom-business/
https://www.courthousenews.com/the-kratom-playbook-working-the-refs/
https://www.courthousenews.com/the-law-and-the-profits-inside-kratoms-political-underbelly/
https://www.courthousenews.com/major-kratom-importers-guilty-plea-stirs-questions/
Research articles mentioned in interview:
Study of 550 Kratom Related Deaths (21 Kratom Alone) Over Two Years https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4495146
A Mild Panic? Media Accounts of Kratom
https://www.tandfonline.com/doi/full/10.1080/01639625.2019.1607114
Patterns of Kratom use and health impact in the US—Results from an online survey
https://pubmed.ncbi.nlm.nih.gov/28521200/
Forensic Implications of Kratom
https://link.springer.com/epdf/10.1007/s40429-023-00477-4?sharing_token=wh-9b_7hinP2jDobkJxOcve4RwlQNchNByi7wbcMAY6YWAp_ltIAKHHRkHjabCt4rfmHk7R0b28KLLHNQO3tpxmNqbgt94y6JvxO25oe_5u8XLWeFn7APmIBgzqo-yzekFy09CcczTqwUO9NdCwkzz4mr-fhkdiSsE4ZNS5_MAY=
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CONTACT THE SHOW
Voice: 313-437-7720
Email: kratomsobriety@gmail.com
https://kratomsobriety.com
Sunday Oct 15, 2023
Sunday Oct 15, 2023
Preview of an upcoming episode with journalist Edward Erickson, Jr. and his articles about the kratom industry. Decima interviews Sammy who quit kratom 5 years ago! Jacob takes a look at kratom and toxic metals.
RESOURCE OF WEEK
https://nextdistro.org/naloxone
If you are using kratom and are at-risk of mixing it with stronger drugs known to cause respiratory depression, please have naloxone/narcan around for an accidental overdose so others can revive you, or so you can help friends or family members. Kratom does not appear to cause people to stop breathing in the same way classic opioids do. There is at least one case report of the use of naloxone to reverse the effects of kratom, but in general it appears it won't be helpful with a kratom alone overdose - but kratom mixed with polydrug intoxication - naloxone can save a life. You never know, a kratom product may be adulterated or someone you think is only taking kratom, may have been hiding their harder substance abuse.
Kratom (Mitragynine) Ingestion Requiring Naloxone Reversalhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366391
Kratom-Induced Acute Respiratory Distress Syndrome (ARDS)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084802
KRATOM IN THE HEADLINES
Heavy Metals & Kratom
https://www.sciencedirect.com/science/article/abs/pii/S2468170923000103?via%3Dihub
https://www.healthline.com/health-news/what-to-know-about-heavy-metals-in-kratom#Dangers-of-heavy-metals
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https://www.youtube.com/@KratomSobriety
CONTACT THE SHOW
Voice: 313-437-7720
Email: kratomsobriety@gmail.com
https://kratomsobriety.com
Sunday Oct 08, 2023
Sunday Oct 08, 2023
Kratom and hair loss. Wes tells how he kicked the kava/kratom "little blue devils". Drugs that use CYP3A to break down may be inhibited by kratom consumption, and hence may cause a dangerous overdose condition with some common pharmaceuticals.
RESOURCE OF WEEK
Kratom can affect certain forms of CYP enzymes that are crucial in the metabolization of other compounds such as pharmaceutical drugs. This can cause adverse drug reactions such as serotonin syndrome, various organ toxicity, and even death in some instances. Common examples: Elavil, Endep, Tofranil, Praminil, Anafranil, Celexa, Lexapro, Cipralex, Paxil, Seroxat, Prozac, Sarafem, Effexor, Effexor XR, Desyrel, Oleptro, Serzone, Buspar, Remeron, Zispin, Seroquel, Abilify, Geodon, Latuda, Clozaril, Erythromycin, Clarithromycin, Telithromycin, Rifampin (Rifampicin), and Rifabutin. “Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom.” Clinical Pharmacology and Therapeutics, March 2023. https://doi.org/10.1002/cpt.2891.
KRATOM IN THE HEADLINES
https://kratomsobriety.com/f/kratom-advocate-extremism-fails-to-prevent-ban-in-zachary-la
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https://www.youtube.com/@KratomSobriety
CONTACT THE SHOW
Voice: 313-437-7720
Email: kratomsobriety@gmail.com
https://kratomsobriety.com
Sunday Oct 01, 2023
Sunday Oct 01, 2023
Lori shares how she broke her 10 year long kratom addiction (dependency + inability to stop despite a strong desire to quit and negative consequences - financial and health in her case). She really relates to the quote from the Lord of Rings in which Bilbo tells Gandalf that “I feel thin, sort of stretched, like butter scraped over too much bread.” Things are much better today kratom-free. NOTE: Kratom in the Headlines and Resource of the Week will return next episode.
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CONTACT THE SHOW
Voice: 313-437-7720
Email: kratomsobriety@gmail.com
https://kratomsobriety.com
Sunday Sep 24, 2023
Sunday Sep 24, 2023
Read the Article: https://kratomsobriety.com/f/kratom-regulatory-reform
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CONTACT THE SHOW
Voice: 313-437-7720
Email: kratomsobriety@gmail.com
https://kratomsobriety.com
Sunday Sep 17, 2023
Sunday Sep 17, 2023
Kava/kratom drink special. Interview best listened to on speakers not headphones sorry for audio issues. John tells how he kicked kava/kratom shots: "You have to work on the little blue bottle hole inside you that led you to get addicted." See previous episode on potential fermenting of kratom that may why kratom/kava drinks maybe so addictive for many people: https://kratomsobriety.podbean.com/e/e21-kratom-and-pseudoindoxyl-metabolites/.
RESOURCES OF THE WEEK
https://www.arnslaw.com/active-investigations/feelfree/
https://www.reddit.com/r/Quittingfeelfree/comments/1616m4r/ff_case_update/
KRATOM IN THE HEADLINES
https://medium.com/@jwross/3-reasons-why-you-should-avoid-natural-flavors-5b1b25899182
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https://www.youtube.com/@KratomSobriety
CONTACT THE SHOW
Voice: 313-437-7720
Email: kratomsobriety@gmail.com
https://kratomsobriety.com
Wednesday Sep 13, 2023
Wednesday Sep 13, 2023
Guest analysis about kratom pharmacology with academic references for this episode's commentary. Contact info at end of the show notes if you are seeking help quitting kratom.
SOURCES
Angyal, Péter, Kristóf Hegedüs, Bence Balázs Mészáros, János Daru, Ádám Dudás, Anna Rita Galambos, Nariman Essmat, Mahmoud Al-Khrasani, Szilárd Varga, and Tibor Soós. 2023a. “Gram-Scale Syntheses of Kratom Pseudoindoxyl Metabolites: Illuminating the Dynamic Stereochemistry and the Resulting Structural Plasticity of Mitragynine Pseudoindoxyl.” ChemRxiv, February. https://chemrxiv.org/engage/chemrxiv/article-details/63dab15989c04b6693c92cba
Angyal, Péter, Kristóf Hegedüs, Bence Balázs Mészáros, János Daru, Ádám Dudás, Anna Rita Galambos, Nariman Essmat, Mahmoud Al-Khrasani, Szilárd Varga, and Tibor Soós. 2023b. “Total Synthesis and Structural Plasticity of Kratom Pseudoindoxyl Metabolites.” Angewandte Chemie , June, e202303700. https://doi.org/10.1002/anie.202303700
Chakraborty, Soumen, Rajendra Uprety, Amal E. Daibani, Valerie L. Rouzic, Amanda Hunkele, Kevin Appourchaux, Shainnel O. Eans, et al. 2021. “Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom.” ACS Chemical Neuroscience 12 (14): 2661–78. https://doi.org/10.1021/acschemneuro.1c00149
Chakraborty, Soumen, Rajendra Uprety, Samuel T. Slocum, Takeshi Irie, Valerie Le Rouzic, Xiaohai Li, Lisa L. Wilson, et al. 2021. “Oxidative Metabolism as a Modulator of Kratom’s Biological Actions.” Journal of Medicinal Chemistry 64 (22): 16553–72. https://doi.org/10.1021/acs.jmedchem.1c01111
Ford, Nigel. 2021. “What Is Fermented Kratom?” Kratom.org. October 8, 2021. https://kratom.org/guides/fermented-kratom
Kamble, Shyam H., Francisco León, Tamara I. King, Erin C. Berthold, Carolina Lopera-Londoño, Kanumuri Siva Rama Raju, Aidan J. Hampson, et al. 2020. “Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy.” ACS Pharmacology & Translational Science 3 (6): 1063–68. https://doi.org/10.1021/acsptsci.0c00075
Schaffenburg, William C., Benjamin N. Lockshin, and Cynthia M. C. DeKlotz. 2021. “Polymorphisms: Why Individual Drug Responses Vary.” In Comprehensive Dermatologic Drug Therapy (Fourth Edition), edited by Stephen E. Wolverton, 21–33.e2. Elsevier. https://doi.org/10.1016/B978-0-323-61211-1.00003-6
Takayama, Hiromitsu, Hayato Ishikawa, Mika Kurihara, Mariko Kitajima, Norio Aimi, Dhavadee Ponglux, Fumi Koyama, et al. 2002. “Studies on the Synthesis and Opioid Agonistic Activities of Mitragynine-Related Indole Alkaloids: Discovery of Opioid Agonists Structurally Different from Other Opioid Ligands.” Journal of Medicinal Chemistry 45 (9): 1949–56. https://doi.org/10.1021/jm010576e
Trescot, Andrea M., Sukdeb Datta, Marion Lee, and Hans Hansen. 2008. “Opioid Pharmacology.” Pain Physician 2008 (11): S133–53. https://www.painphysicianjournal.com/current/pdf?article=OTg3&journal=42
Váradi, András, Gina F. Marrone, Travis C. Palmer, Ankita Narayan, Márton R. Szabó, Valerie Le Rouzic, Steven G. Grinnell, et al. 2016. “Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit ß-Arrestin-2.” Journal of Medicinal Chemistry 59 (18): 8381–97. https://doi.org/10.1021/acs.jmedchem.6b00748
Wikipedia contributors. 2023. “Mitragynine Pseudoindoxyl.” Wikipedia, The Free Encyclopedia. August 15, 2023. https://en.wikipedia.org/w/index.php?title=Mitragynine_pseudoindoxyl&oldid=1170554478
Yamamoto, L. T., S. Horie, H. Takayama, N. Aimi, S. Sakai, S. Yano, J. Shan, P. K. Pang, D. Ponglux, and K. Watanabe. 1999. “Opioid Receptor Agonistic Characteristics of Mitragynine Pseudoindoxyl in Comparison with Mitragynine Derived from Thai Medicinal Plant Mitragyna Speciosa.” General Pharmacology 33 (1): 73–81. https://doi.org/10.1016/s0306-3623(98)00265-1
Zarembo, J. E., B. Douglas, J. Valenta, and J. A. Weisbach. 1974. “Metabolites of Mitragynine.” Journal of Pharmaceutical Sciences 63 (9): 1407–15. https://doi.org/10.1002/jps.2600630916
Zhou, Yuchen, Steven Ramsey, Davide Provasi, Amal El Daibani, Kevin Appourchaux, Soumen Chakraborty, Abhijeet Kapoor, Tao Che, Susruta Majumdar, and Marta Filizola. 2021. “Predicted Mode of Binding to and Allosteric Modulation of the µ-Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo.” Biochemistry 60 (18): 1420–29. https://doi.org/10.1021/acs.biochem.0c00658
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CONTACT THE SHOW
Voice: 313-437-7720
Email: kratomsobriety@gmail.com
https://kratomsobriety.com